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Now in Photochem Photobiol: Hypericin Hydroquinone as a Red/Far-red Photosensitizer

Absorbance spectra of HYP-H (a), reoxidized HYP-H (b), and HYP (c). The inset shows solutions of HYP (L) and HYP-H (R). Figure is from [1].

Hypericin (HYP) is a red-colored pigment present in species of the genus Hypericum (St. John's wort). HYP absorbs strongly in the green-orange spectral region (~500-600 nm), and the reduced form of HYP (HYP-H) absorbs strongly in the red/far-red region (~640-700 nm). Recent research has shown that hypericin may be a useful agent for photodynamic therapy (PDT). In PDT, a photosensitive agent is administered to a patient and is then activated by light, thus destroying cancerous or other harmful cells.

In the current issue of Photochemistry and Photobiology, Theodossiou et al. [1] report on their recent studies of HYP and HYP-H in cultured DU-145 (prostate cancer) cells. They found that HYP and HYP-H localize to mitochondria and that both are cytotoxic. This is the first report to document significant phototoxicity of HYP-H.

[1] Theodossiou TA, Tsiourvas D, Hothersall JS (2010) Hypericin hydroquinone: potential as a red/far-red photosensitiser? Photochem Photobiol 86: 18-22. [PubMed Link]

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