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29th Annual Meeting of the American Society for Photobiology
Downtown Marriott
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MONDAY, JULY 9
| 7:00-8:00am Chicago A-D |
POSTER VIEWING II and Continental Breakfast | |
| 8:00-9:00am Chicago E |
SCHOOL LECTURE II: Phototoxicology: Standards
and Regulations in Photobiology, Paper 57 Paul Donald Forbes Charles River Laboratories (Argus Division), Horsham, PA |
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| 9:00-12:00pm Chicago E |
SYMPOSIUM 6: Photocarcinogenesis: Mechanisms and Prevention, Papers
58-63 Chairs: Hasan Mukhtar, Case Western Reserve University, Cleveland, OH and Honnavara Ananthaswamy, M.D. Anderson Cancer Center, Houston, TX This symposium sponsored in part by Univera Pharmaceuticals, Inc. Photocarcinogenesis represents the interplay of several biochemical and genetic factors that ultimately lead to development of skin cancer, the incidence of which continues to increase. This symposium will highlight events that are important in photocarcinogenesis. Novel approaches for prevention of these cancers will also be discussed. |
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| 9:00am | Cellular and Molecular Changes During
Photocarcinogenesis, Paper 58 H. Ananthaswamy1, A. Pacifico1,3, A. Ouhtit1, S. Bolshakov1, S. Chimenti2 and K. Peris3 1M.D. Anderson Cancer Center, Houston, TX, 2University of Tor Vergata, Rome, Italy and 3University of l'Aquila, Italy |
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| 9:25am | Targeting UVB Induced AP-1 Activation
for Chemoprevention of Skin Cancer, Paper 59 G.T. Bowden1, W. Chen2, J. Gregus1, Q. Tang1 and Z. Dong3 1The University of Arizona, Tucson, AZ, 2Scripps Research Institute, LA Jolla, CA and 3The Hormel Institute, Austin, TX |
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| 9:50am | Cyclooxygenase as a Target for Prevention
of UV-Induced Skin Carcinogenesis, Paper 60 S. Fischer1, H. Lo1 and R. Lubet2 1University of Texas M.D. Anderson Cancer Center, Houston, TX and 2National Institutes of Health, Bethesda, MD |
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| 10:15am | Break | |
| 10:30am | UV Carcinogenesis in Heterozygous p53
Knockout Hairless Mice; Conversion to More Malignant Tumors, Paper
61 H. van Kranen2, R. Berg3, A. Westerman-de Vries2, H. Rebel1, P. Wester2 and F. de Gruijl1 1Leiden University Medical Center, Leiden, 2RIVM/National Institute for Health and the Environment and 3University Medical Center, Utrecht, The Netherlands |
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| 10:55am | Photochemoprotection Through Botanical
Antioxidants, Paper 62 H. Mukhtar1, N. Ahmad1, S. Katiyar2 and C. Elmets2 1Case Western Reserve University, Cleveland, OH and 2University of Alabama, Birmingham, AL |
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| 11:20am | Immuno-10, a Modified Aloe barbadensis
Polysaccharide, Restores UVB Induced Immunosuppression, Paper 63 T. Nichols, Z. Qui, K. Jones, Q. Jia, S. Vecchiarelli and S. Orndorff Univera Pharmaceuticals, Inc., Broomfield, CO |
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| 9:00-12:00pm Denver/Houston/ Kansas City |
SYMPOSIUM 7: Photoactive Retinal Proteins and Transduction Processes,
Papers 64-69 Chairs: Rosalie Crouch, Medical University of South Carolina, Charleston, SC and Thomas Ebrey, University of Washington, Seattle, WA The structure and function of several integral membrane proteins which contain retinal as their chromophore will be discussed. Phototransduction in these retinal proteins will be considered. One area of emphasis will be on the differences in the two visual photoreceptors, rods and cones. The use of fluorescence in following the retinal reduction pathway will be presented. The mechanisms of the energy transformation and signaling pathways of these pigments ranging from bacteriorhodopsin to rhodopsins from several vertebrate species as well as an algae form will be discussed. |
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| 9:00am | Activity of Cone Visual Pigments Regenerated
with 9-Desmethylretinal, Paper 64 R. Crouch1, M. Kono1, D. Oprian2, J. Das1 and D. Corson1 1Medical University of South Carolina, Charleston, SC and 2Brandeis University, Waltham, MA |
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| 9:25am | Evidence for the Mechanism of Reduction
of Retinal to Retinol in Intact Salamander Rods, Paper 65 C. Cornwall1, E. Tsina1, Y. Koutalos2, C. Chen2 and R. Crouch3 1Boston University School of Medicine, Boston, MA, 2University of Colorado School of Medicine and 3Medical University of South Carolina, Charleston, SC |
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| 9:50am | Molecular Control of Visual Pigment Properties,
Paper 66 T. Ebrey and Y. Takahashi University of Washington, Seattle, WA |
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| 10:20am | Break | |
| 10:30am | The Effect of Steric Hindrance Between
Retinal and Protein on the Function of Rhodopsin, Paper 67 W. Gärtner and A. Ockenfels Max-Planck-Institut fuer Strahlenchemie, Mülheim, Germany |
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| 11:00am | The Expanding Family of Microbial Rhodopsins,
Paper 68 J. Spudich, E. Spudich and K-H. Jung University of Texas Medical School, Houston, TX |
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| 11:30am | Participation of Hydrogen Bonding Residues
and Water Molecules in Light-Driven Proton Transport by Bacteriorhodopsin
(bR), Paper 69 S. Balashov1, A. Maeda1, E. Imasheva1, M. Lu1, R. Govindjee1, T. Ebrey2, Y. Chen3, D. Menick3 and R. Crouch3 1University of Illinois, Urbana, IL, 2University of Washington, Seattle, WA and 3Medical University of South Carolina, Charleston, SC |
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| 9:00-12:00pm Chicago F-G |
SYMPOSIUM 8: Applications of Spectroscopy, Papers 70-74 Chair: Linda Peteanu, Carnegie Mellon University, Pittsburgh, PA Techniques such as ultra-fast transient absorption spectroscopy, near field and confocal microscopies, as well as fluorescence and Stark spectroscopy are amongst those in the repertoire of experimentalists studying problems of biological interest. This symposium will cover applications of these methods involving the mechanism of action of B12 enzymes, the morphology and photo-physics of ocular lipofuscin, the photo-damage repair mechanisms of DNA, and the use of dyes as reporter species for the structure and dynamics of DNA. |
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| 9:00am | The Chromophores, Spectroscopy, and Photochemistry
of Human Ocular Lipofuscin, Paper 70 J. Simon1, L. Lamb1, N. Haralampus-Grynaviski1 and T. Sarna2 1Duke University, Durham, NC and 2Jagiellonian University, Krakow, Poland |
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| 9:35am | Time-Resolved Spectroscopic Studies of
B12 Coenzymes, Paper 71 R.Sension, A. Cole, L. Yoder and J. Shiang University of Michigan, Ann Arbor, MI |
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| 10:10am | Break | |
| 10:20am | Ultrafast Photoprocesses in Nucleic Acids:
New Insights into Ancient Sunscreens, Paper 72 B. Kohler, J-M. Pecourt and J. Peon Ohio State University, Columbus, OH |
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| 10:55am | Local Dynamics in DNA by Ultrafast Stokes-Shift
Spectroscopy, Paper 73 E. Brauns1, M. Madaras2, R. Coleman2, C. Murphy1 and M. Berg1 1University of South Carolina, Columbia, SC and 2Ohio State University, Columbus, OH |
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| 11:30am | Using Stark Spectroscopy to Probe Charge-Transfer
States in Molecules and Aggregates Bound to DNA, Paper 74 A. Chowdhury, I. Raheem, L. Peteanu, I. Dilek, B. Armitage, M. Kofke and D. Yaron Carnegie Mellon University, Pittsburgh, PA |
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| 9:00-11:45am Chicago H |
PLATFORM SESSION 3: PDT 2/Photochemistry, Papers 75-83,
106 Chairs: David Thompson, Purdue University, West Lafayette, IN and Duska Separovic, Wayne State University, Detroit, MI |
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| 9:00am | Chloroaluminum Phthalocyanine Tetrasulfonate
Delivered via Acid-Labile Diplasmenylcholine-Folate Liposomes: Intracellular
Localization and Synergistic Phototoxicity, Paper 75 M. Qualls and D. Thompson Purdue University, West Lafayette, IN |
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| 9:15am | Cell-to-Cell Interactions in Photodynamic
Inactivation of Cells, Paper 76 J. Dahle, H. Steen and J. Moan The Norwegian Radium Hospital, Oslo, Norway |
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| 9:30am | FADD Null Mouse Embryonic Fibroblasts
Undergo Apoptosis After Photosensitization with the Silicon Phthalocyanine
Pc 4, Paper 77 B. Nagy1,2, W-C. Yeh3, T. Mak3, S-M. Chiu1 and D. Separovic1,4 1Case Western Reserve University, Cleveland, OH, 2University of Zagreb, 3University of Toronto and 4Wayne State University, Detroit, MI |
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| 9:45am | Synthesis and Properties of Novel Phthalocyanine-Based
Photosensitizers for Photodynamic Therapy, Paper 78 W. Sharman and J. van Lier University of Sherbrooke, Sherbrooke, Canada |
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| 10:00am | Preparation and Properties of Heteroatom
Analogues of the Organosilicon PDT Drug Pc 4, Paper 106 M. Kenney, Y-S Li and H. Wu Case Western Reserve University, Cleveland, OH |
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| 10:15am | Break | |
| 10:30am | Characterization of Plasmenycholine Vesicle
Photooxidation Products Formed via AlPcS44-Sensitization, Paper
79 H.D. Inerowicz, H. Dorota, J. Grove and D. Thompson Purdue University, West Lafayette, IN |
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| 10:45am | A Model for the Stereoselectivity of
Photochemical Hydrogen Abstraction from Lipids by Chiral Drugs, Paper
80 L. Martínez, A. Samadi, F. Boscá, I. Morera and M. Miranda Universidad Politécnica de Valencia, Valencia, Spain |
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| 11:00am | The Photodamage of DNA and Protein by
Ochratoxin A, Paper 81 Y. Il'ichev, J. Perry and J. Simon Duke University, Durham, NC |
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| 11:15am | The Vertical Depth of Porphyrin in a
Lipid Bilayer and the Membrane Properties Affect the Sensitizing Efficiency,
Paper 82 B. Ehrenberg1, A. Lavi1 and K. Smith2 1Bar Ilan University, Ramat Gan, Israel and 2University of California, Davis, CA |
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| 11:30am | Characterization of Actinic Power Dependence
in Systems which Undergo IrreversibleMultiphoton-Induced Photochemistry,
Paper 83 M. Masthay1 and M. Helvenston2 1Murray State University, Murray, KY and 2New Mexico Highland University, Las Vegas, NV |
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| 12:00-1:30pm | Lunch Break (on own) | |
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| 12:00-1:00pm Los Angeles |
PAST PRESIDENTS' LUNCH | |
| 1:30-2:30pm Chicago E |
SPECIAL LECTURE II: ASP New Investigator
Lecture Time-Resolved Reflectance and Transmittance Spectroscopy and Imaging for Medical Diagnostics, Paper 84 Paola Taroni, Politecnico di Milano, Milan, Italy |
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| 2:30-5:30pm Chicago E |
SYMPOSIUM 9: Photoprotection, Papers 85-91 Chair: Henry Lim, Henry Ford Hospital, Detroit, MI This symposium sponsored in part by Ciba Specialty Chemicals, Dermik Laboratories, Fujisawa Healthcare and LaRoche Posay USA. The most current topics on photoprotection will be discussed. These include sunscreens and photoimmunology, photoaging, the role of fabrics and new agents in photoprotection, sunscreen UVA protection, and sunscreen product compliance. At the end of the session, the audience should have a good overview of the current topics in photoprotection. |
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| 2:30pm | Introduction H. Lim |
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| 2:35pm | Sunscreens and Immunoprotection in Humans,
Paper 85 A. Young, D. Kelly, P. Seed and S. Walker King's College, London, United Kingdom |
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| 3:00pm | UVA Filters in Sunscreens Enhance the
Protection Against Photoimmunosuppression, Paper 86 A. Fourtanier1, D. Moyal1, E. Baron2, D. Compan1 and S. Stevens2 1L'Oreal Recherche, Paris, France and 2Case Western Reserve University, Cleveland, OH |
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| 3:25pm | Antioxidants on Photoaging Prevention,
Paper 87 S. Kang, G. Fisher and J. Voorhees University of Michigan Medical Center, Ann Arbor, MI |
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| 3:50pm | Photoprotection of Fabrics, Paper
88 W. Morison Johns Hopkins University, Baltimore, MD |
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| 4:15pm | New Agents in Photoprotection, Paper
89 C. Rosen University of Toronto, Canada |
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| 4:40pm | UVA Protection of Sunscreen,
Paper 90 H. Lim Henry Ford Health System, Detroit, MI |
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| 5:05pm | Sunscreen Product Compliance,
Paper 91 J. Nash The Procter & Gamble Company, Cincinnati, OH |
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| 2:30-5:30pm Chicago F-G |
SYMPOISUM 10: Consequences of Oxidative Stress: Reactive Oxygen-Mediated
Signaling Processes, Papers 92-96 Chair: Nancy Oleinick, Case Western Reserve University, Cleveland, OH and Douglas R. Spitz, University of Iowa, Iowa City, IA Jointly sponsored by the American Society for Photobiology and the Radiation Research Society Both ionizing and non-ionizing radiations begin their interaction with biological systems by producing reactive oxygen species (ROS), including singlet oxygen, superoxide, and/or hydroxyl radical. ROS are also produced by processes intrinsic to cells, especially by mitochondria, and these processes can be enhanced in the absence of glucose, the most important source of reducing equivalents. ROS can cause direct oxidative changes in cellular constituents and can activate specific stress pathways whose function can be to repair the damage or to signal cell death. In some cases, the techniques used to monitor cell responses can themselves produce ROS. This symposium will explore these and other sources of reactive oxygen and some of the important consequences of oxidative stress. |
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| 2:30pm | Oxygen Dependence of Intracellular Generation
of Reactive Oxygen Species, Paper 92 N. Chandel Northwestern University Medical School, Chicago, IL |
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| 3:00pm | Mitochondrial Reactive Oxygen Species
in Cell Injury, Paper 93 A-L. Nieminen Case Western Reserve University, Cleveland, OH |
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| 3:30pm | Sources and Remedies of Photodamage in
Live Cell Microscopy, Paper 94 P. Hockberger Northwestern University Medical School, Chicago, IL |
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| 4:00pm | Role of the Mitogen Activated Protein
Kinase (MAPK) Signaling Pathways in the Sensitivity of Human Cells to Photodynamic
Therapy, Paper 95 Z. Tong1,2, G. Singh1,2 and A. Rainbow1 1McMaster University and 2Hamilton Regional Cancer Centre, Hamilton, Canada |
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| 4:30pm | Glucose Deprivation-Induced Oxidative
Stress in Human Tumor Cells: A Fundamental Defect in Metabolism?, Paper
96 D. Spitz University of Iowa, Iowa City, IA |
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| 5:00pm | General Discussion | |
| 2:30-4:30pm Chicago H |
PLATFORM SESSION 4: Photomedicine, Papers 97-103 Chairs: Janet Morgan, Roswell Park Cancer Institute, Buffalo, NY and Craig Dees, Photogen, Knoxville, TN |
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| 2:30pm | UVA Irradiation Enhances Metastatic Properties
of Melanoma Cells, Paper 97 R. Pastila and D. Leszczynski STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland |
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| 2:45pm | Three-Dimensional Targeting of Photodynamic
Damage to Specific DNA Sequences, Paper 98 D. Oh1,2, B. King3, S. Boxer3 and P. Hanawalt3 1University of California, San Francisco, CA , 2San Francisco Veterans Administration Medical Center, San Francisco, CA and 3Stanford University, CA |
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| 3:00pm | Low Level Visible Light Stimulates Changes
in Reactive Oxygen Species and in Intracellular Calcium Concentration,
Paper 99 R. Lavie, A. Shaniberg, H. Friedmann, M. Sinyakov, T. Zinman, A. Isaack and R. Lubart Bar-Ilan University, Ramat-Gan, Israel |
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| 3:15pm | Break | |
| 3:30pm | Repair of Corneal Wounds in vivo by Photochemical
Tissue Bonding, Paper 100 C. Proano, E. Jones, L. Mulroy, D. Azar, I. Kochevar and R. Redmond Harvard Medical School, Boston, MA |
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| 3:45pm | The Reactions of Human Skin to UVA Radiation
(330-400 nm), Paper 101 T. Sakamaki1, W.D. Tian1, D. Moyal2, A. Chardon2 and N. Kollias1 1Harvard Medical School and 2L'Oreal Research, Clichy, France |
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| 4:00pm | Treatment of Oral Candidiasis Using Methylene
Blue Mediated PDT in a Murine Model, Paper 102 M. Teichert, M. Usacheva and M. Biel Advanced Photodynamic Technologies, Inc., Minneapolis, MN |
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| 4:15pm | Use of Halogenated Xanthenes to Specifically
Target Diseased Tissue, Paper 103 C. Dees, J. Harkins, T. Scott and E. Wachter Photogen, Inc., Knoxville, TN |
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| 5:30-6:30pm Chicago E |
SPECIAL LECTURE III: Phototherapy in
the Blue. Still Saving Lives after 43 Years, Paper 104 Antony McDonagh University of California, San Francisco, CA |
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| 5:30-7:00pm Chicago A-D |
POSTER SESSION I, Papers 105-142 | |
| Photochemistry, Papers 105-113
Structural Study of Retinochrome Using
Double Bond-Locked Analogue Chromophores, Paper 105 Dramatic Modification of Fluoroquinolones
Photoreactivity Through Self-Incorporation of Their Cationic Forms in
SDS Micelles. A Right Approach in the Design of Biocompatible Drug-Carrier
Devices?, Paper 107 Studies of the Photochemical Properties
of HIDD, Paper 108 Time-Resolved Spectroscopic Measurements
of Anaerobically Modified "-Crystallin and Aged Human Lens Protein,
Paper 109 Oxidative Strand Cleavage Initiated
by Two Photon-Induced Photoionization of Site-Specifically Incorporated
2-Aminopurine Residues in Oligonucleotides, Paper 110 Differences in Photochemical Behavior
of Organic Molecules Between Lipid Membrane and Homogeneous Solution,
Paper 111 Photochemical Reduction of Tirapazamine
(3-Amino-1,2,4-Benzotriazine 1,4-Dioxide) to a Nitroxide Free Radical,
Paper 112 On the Fluorescence of Mammalian Collagen,
Paper 113 |
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| Photodynamic Therapy, Papers 114-127
Low-Dose Merocyanine 540-PDT Potentiates
the Antitumor Effect of Crystal Violet-PDT, Paper 114 Enhanced Photodynamic Therapy Efficacy
with Inducible Suicide Gene Therapy Controlled by the grp Promoter,
Paper 115 Depletion of ATP and Cytosolic Ca2+
Accelerate PDT-Induced Firing Inhibition and Death of Isolated Nerve Cell,
Paper 116 Action of *-Aminolevulinic Acid and
*-Aminolevulinic Acid Methyl Ester on Human Cancer Cells, Paper
117 The Interaction Bewteen the Phenothiazine
Dyes as Photosensitizers and Gram Negative Bacteria and their Lipopolysaccharides,
Paper 118 Normal Tissue Tolerance of the Photosensitizer
Benzoporphyrin Derivative (Verteporfin) in an Oral and Laryngeal Canine
Model, Paper 119 Photodynamic Activities of Benzochlorin
and Porphycene Derivatives on Nasopharyngeal Carcinoma Cells, Paper
120 Increased Expression of Matrix Metalloproteinases
and Integrins in a Mouse Mammary Carcinoma Following Photofrin-Mediated
Photodynamic Therapy or Laser-Induced Hyperthermia, Paper 121 Partition Coefficients Determination
of 5-ALA Ester Derivatives to Cutaneous Delivery in PDT, Paper
122 Transdermic Patches for Photodynamic
Therapy of Superficial Skin Lesions, Paper 123 Comparison of Apoptotic and Necrotic
Response Following 5-Aminolaevulinic Acid-Based Photodynamic Therapy,
Paper 124 Fluence and Fluence Rate Dependence
of PDT Induced Vascular Permeability, Paper 125 Unique Excited State Properties of
a Bacteriochlorophyll-Serine Conjugate - the Key to its Action as a Sensitizer
in PDT?, Paper 126 Modulation of Nitric Oxide Levels in
Human Cancer cells Undergoing PDT with Photofrin: Implications for the
Use of Nitric Oxide in Photodynamic Therapy, Paper 127 |
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| Photoimmunology, Papers 128-130
Does Cutaneous Ultraviolet (UV) Radiation
Inhibit Transcutaneous Immunization (TCI) in Cattle, Paper 128 An Investigation into the Effects of
Narrow-Range infrared Radiation on the Osteosynthesis and Immune Status
in Shin Fractures in Rats, Paper 129 Nitric Oxide Contributes to Solar-Stimulated
Ultraviolet Radiation-Induced Immunosuppression in Humans, Paper
130 |
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| Photomedicine, Papers 131-135
PK11195 Mediates Enhanced Phototoxcity
by Increasing Mitrochondrial Uptake of Photosensitizer via the Peripheral
Benzodiazepine Receptor, Paper 131 Predicting of Skin Sensibility Using
Skin Types and Colorimetry, Paper, 132 Photodynamic Activity of Phthalocyanine
Photosensitizer Pc 4 on B16 Murine Melanoma, Paper 133 Photochemical Tissue Bonding in Skin
Grafting - An ex vivo Study, Paper 134 Effects of Topically Applied Glycolic
Acid (GA) on the Sensitivity of Human Skin to UV-Induced Damage,
Paper 135 |
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| Photosensitizer Development, Papers 136-139
Intracellular Localization and Photobleaching
of Hypericin, Paper 136 Ruthenium Nitrosyl Complexes as Nitric
Oxide Deliverers Capable to be Used in PDT, Paper 137 Enzymatic Synthesis of New Cationic
Photosensitizers, Paper 138 New Cationic Photosensitizers for the
Selective Destruction of Tumor Cells Via Mitochondrial Targeting,
Paper 139 |
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| Signal Transduction, Papers 140-142
Protein Kinase C Functions Downstream
of the Death Receptor Signaling Complex in Mediating Inhibition of Singlet
Oxygen-Induced Apoptosis, Paper 140 UVA Irradiation-Induced Activation
of AP-1 and Characterization of the AP-1 Complex in the Human Keratinocyte
Cell Line HaCaT, Paper 141 P53 Protein and p21 WAF Inhibitor Protein
Co-Assocate with Jun Amino Terminal Kinase (JNK1), Paper 142 |
