29th Annual Meeting of the American Society for Photobiology Downtown Marriott Chicago, IL . . . . . . . . . . . . . . . . . . . . . . July 7-12, 2001

TUESDAY, JULY 10

7:00-8:00am Chicago A-D		POSTER VIEWING III and Continental Breakfast
8:00-9:00am Chicago E		SCHOOL LECTURE III: Towards the Jablonski Diagram for PDT In-Vivo, Paper 143 Brian Wilson Ontario Cancer Institute, University of Toronto, Toronto, Canada
9:00-12:00pm Chicago E		SYMPOSIUM 11: PDT from Bench to Bedside - The Roswell Connection, Part 1, Papers 144-149 Chair: Barbara Henderson, Roswell Park Cancer Institute, Buffalo, NY This symposium sponsored in part by Oncologic Foundation of Buffalo. One of the missions of a Comprehensive Cancer Center is to carry out translational research. Photodynamic therapy research is an intensely translational field, and Roswell Park Cancer Institute has been at the forefront of this translational effort. This symposium has been organized to acknowledge this central role. The major question asked in translational research is "How do data derived from molecular, cellular and animal models translate to the human situation?" The scientific focus of this symposium will be on answering this question for PDT. Current research will be presented that has completed the path from the laboratory to the clinic.
9:00am		Introduction B. Henderson and C. Gomer
9:10am		From the Chem Lab to the Patient. Drug Development at Roswell Park Cancer Institute, Paper 144 T. Dougherty, R. Pandey, B. Henderson, D. Bellnier and W. Potter Roswell Park Cancer Institute, Buffalo, NY
9:35am		Challenges of Commercialization of PDT - the Visudyne Example, Paper 145 J. Levy QLT Phototherapeutics, Inc., Vancouver, Canada
10:00am		PDT for Skin Cancers: What Do We Know About How to Go?, Paper 146 A. Oseroff, S. Shieh, N. Frawley, L. Blumenson, J. Parsons, W. Potter, A. Graham, B. Henderson and T. Dougherty Roswell Park Cancer Institute, Buffalo, NY
10:25am		Break
10:45am		Treatment of Menorrhagia by ALA PDT - From Laboratory to Clinic, Paper 147 S. Brown1, M. Gannon2, D. Vernon1 and J. Holroyd1 1University of Leeds, Leeds, United Kingdom and 2Mullingar General Hospital, Co Westmeath, Eire
11:10am		A Phthalocyanine Photosensitizer for Photodynamic Therapy, Paper 148 N. Oleinick, C. Hoppel, M. Kenny, T. Kinsella, H. Mukhtar, A-L. Nieminen, C. Sibata, S. Remick, S. Stevens and C. Whitacre Case Western Reserve University, Cleveland, OH
11:35am		Translating Optical Dosimetry to Practical Bedside PDT Protocols, Paper 149 S. Jacques Oregon Medical Laser Center, Portland, OR
9:00-12:00pm Chicago F-G		SYMPOSIUM 12: Pros and Cons of Herbal Medicine, Paper 150-157 Chair: Joan Roberts, Fordham University, New York, NY Herbs and plant-derived tonics have been used for thousands of years to maintain health and prevent disease. In recent years, these natural products have been sold as over-the-counter remedies for a variety of disorders ranging from insomnia and weight loss to cures for viral infections and cancer. At this time, there are no comprehensive evaluations of the safety and efficacy of these products. Furthermore there are no specific standards for the either the purity of the samples nor the exact concentration of the active materials contained in the product that is sold. Thus one product offered by different manufactures may contain substantially different dosages of active ingredient. Nonetheless, certain herbs and phyto-nutrient foods are widely used and in some cases highly effective. Presented in this symposium are the most recent advances in our understanding of the underlying mechanism of action of some of the popular over the counter remedies. All medications, including herbal remedies, have the potential to produce side effects. The toxicity of natural products will also be addressed.
		Part 1
9:00am		Pro's and Con's of Herbal Medications - Overview, Paper 150 J. Roberts
9:15am		The Potential Positive and Negative Effects of Melatonin and Hypericin, Paper 151 J. Roberts Fordham University, New York, NY
9:40am		The Anti-Carcinogenic Properties of Flavonoids from Foods, Paper 152 V. Reeve University of Sydney, Australia
10:05am		Assessment of the Antioxidant and Cytoprotective Abilities of Ginkgo Biloba, Paper 153 D. Balasubramanian L.V. Prasad Eye Institute, Hyderabad, India
10:30am		Break Part II: Techniques to Study Herbal Medications
10:45am		Innovative Techniques for Studying Damage to the Eye Lens by Hypericin (St. John's Wort), Paper 154 J. Wahlman1, J. Trevithick1, M. Hirst1 and J. Roberts2 1University of Western Ontario, London, Canada and 2Fordham University, New York, NY
11:05am		Hypericin Can Bind to and Affect the Lens and its Constituents" An in vitro Spectroscopic Study, Paper 155. A. Sgarbossa and F. Lenci CNR, Istituto Biofisica, Pisa, Italy
11:25am		Techniques for Studying the Photochemistry and Phototoxicity of Topically Applied Herbal Components, Paper 156 C. Chignell NIEHS, NIH, Research Triangle Park, NC
11:45am		Hypericin: A Photodynamic Drug, Paper 157 C. Trevithick and C. Foote University of California, Los Angeles, CA
9:00-11:45am Chicago H		PLATFORM SESSION 5:  Photoimmunology/DNA Damage, Papers 158-165 Chairs: David Mitchell, University of Texas M.D. Anderson Cancer Center, Smithville, TX and Stephen Ullrich, University of Texas M.D. Anderson Cancer Center, Houston, TX
9:00am		Cytokine Polymorphisms Play a Role in the Susceptibility to UVB-Induced Immunomodulation after Hepatitis B Vaccination in Human Volunteers, Paper 158 A. Sleijffers1, B. Yucesoy3 J. Garssen1, G. Boland2, F. De Gruijl2, J. Van Hattum2, W. Van Vloten2, M. Luster3 and H. Van Loveren1 1National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 2University Medical Centre, Utrecht, The Netherlands and 3National Institute for Occupational Safety and Health, Morgantown, WV
9:15am		High Dermal Mast Cell Prevalence is Associated with Basal Cell Carcinoma, but not Squamous Cell Carcinoma Development in Humans, Paper 159 M. Grimbaldeston1, L. Skov2, O Baadsgaard2, G. Marshman1, J. Finlay-Jones1 and P. Hart1 1Flinders University, Adelaide, South Australia and 2Gentofte Hospital, Denmark
9:30am		UV-Induced Platelet Activating Factor Receptor Agonists Cause Immunosuppression, Paper 160 D. Nghiem, J. Walterscheid and S. Ullrich The University of Texas M.D. Anderson Cancer Center, Houston, TX
9:45am		Immunotoxicity Risk Assement for Children with Joint Exposure to Sunlight and Permethrin, Paper, 161 J. Longstreth1,2, B. Blaylock2, M. Prater3, R. Gogal3 and S. Holladay3 1Institute for Global Risk Research, 2University of Louisiana, Monroe, LA and 3VA-MD Regional College of Veterinary Medicine
10:00am		Break
10:15am		Some Medicinal Plants for Oriental Traditional Medicine are Phototoxic in vitro and Can Increase the UVA-Induced Edema, Sunburn Cell Formation and Local Immune Suppression in vivo, Paper 162 N-K. Kang1, E-P. Heo1, K-D. Han1, K-M. Bark1, M-B. Kim2 and T-H. Kim1 1Gyeongsan National University, Chinju, Kyungnam, Korea and 2Medicinal Plant Research Team, the Kyungnam Province, Korea
10:30am		UV Activation of a Platelet Activating Factor-Like Molecule Upregulates COX-2 and IL-10 Transcription in Keratinocytes, Paper 163 J. Walterscheid, D. Nghiem and S. Ullrich The University of Texas M.D. Anderson Cancer Center, Houston, TX
10:45am		Proficiency of Transcription-Coupled Repair of UV-Induced DNA Damage in Mismatch Repair-Deficient Human Adenocarcinoma Cells, Paper 164 P Rochette1, R. Drouin1, N. Bastien1, J-P. Therrien1,2, M.F. Brien2 and E. Drobetsky2 1Laval University, Quebec and 2University of Montreal, Montreal, Canad
11:00am		UV and Visible Light Effects on DNA Synthesis in Cultured Fish Cells, Paper 165 D. Mitchell and M. Byrom University of Texas M.D. Anderson Cancer Center, Smithville, TX
12:00-1:00pm		Lunch Break (on own)
1:00-2:00pm Chicago E		SPECIAL LECTURE IV: Presidential Lecture Bioluminescence: Origins, Functions, Mechanisms and Applications, Paper 166 J. Woodland Hastings Harvard University, Cambridge, MA
2:00-5:00pm Chicago F-G		SYMPOSIUM 13: Optical Bio-Diagnostics, Papers 167-172 Chair: George Murray, Johns Hopkins University, Laurel, MD "Optical Bio-diagnostics" encompasses a broad overview of the means by which optical methods can be used to obtain relevant information about biological systems through processes that selectively monitor relevant chemicals. One aspect of the symposium is concerned with the application of optical sensing strategies to measure molecules of biological significance. Of particular interest are approaches to molecular recognition through biological or biomimetic means. The use of selective chemical receptors equipped with chromophores for sensitive detection has become a means for achieving both high selectivity and high sensitivity, unattainable by other means. Another key component of bio-diagnostics is minimally-invasive sensing and imaging. The combination of selective chemical recognition and imaging will be explored.
2:00pm		Introduction and Overview: Optical Bio-Diagnostics, Paper 167 G. Murray
2:15pm		Molecularly Imprinted Polymer Sensors, Paper 168 D. Lawrence and G. Murray Johns Hopkins University, Laurel, MD
2:45pm		Solvent Effects on Merocyanine 540 (M540) Spectra - A Biological Probe, Paper 169 S. Bae and B. Arnold University of Maryland Baltimore County, Baltimore, MD
3:10pm		Raman and Surface Enhanced Raman Spectroscopy (SERS) for Biological Applications, Paper 170 S.T. Jenkins University of Maryland Dental School, Baltimore, MD
3:40pm		Break
3:55pm		The Photoreactivity of A2-E is Enhanced in Organized Media, Paper 171 E. Gaillard and R. Heckathorn Northern Illinois University, DeKalb, IL
4:25pm		In-Vivo Measurement of Red Blood Cell Velocities Using the Scanning Laser Ophthalmoscope, Paper 172 S. Wajer1 and G. Lutty2 1Johns Hopkins University, Laurel, MD and 2Wilmer Ophthalmological Institute
4:50pm		Closing Remarks G. Murray
2:00-5:00pm Chicago E		SYMPOSIUM 14: PDT from Bench to Bedside - The Roswell Connection, Part 2 Papers 173-177 Chair: Barbara Henderson, Roswell Park Cancer Institute, Buffalo, NY This is a continuation of Symposium 11. Sponsored in Part by Oncologic Foundation of Buffalo.
2:00pm		Understanding the Diverse Effects of PDT Upon Tissue Oxygenation, Paper 173 B. Henderson1, T. Busch2 and A. Oseroff1 1Roswell Park Cancer Institute, Buffalo, NY and 2University of Pennsylvania, Philadelphia, PA
2:25pm		Using Hyperoxygenation to Overcome Tissue Hypoxia in Photodynamic Therapy, Paper 174 F. Hetzel, Q. Chen, Z. Huang and J. Beckers HealthOne Alliance, Denver CO
2:50pm		Intratumor Distributions of Oxygen in PDT-Treated Murine Tumors and the Tumor Nodules of Patients to Receive PDT, Paper 175 T. Busch, S. Evans, S. Hahn, E. Wileyto and C. Koch University of Pennsylvania, Philadelphia, PA
3:15pm		Break
3:25pm		Temptation Island: The Story of PDT, Barrett's Esophagus and p53, Paper 176 K. Wang Mayo Clinic, Rochester, MN
3:50pm		Bench to Bedside - New Directions for PDT, Paper 177 C. Gomer1,2, A. Ferrario1, A. Fisher1, M. Luna1, N. Rucker1 and S. Wong1 1Childrens Hospital Los Angeles and 2University of Southern California, Los Angeles, CA
4:15pm		ROUNDTABLE DISCUSSION
2:00-4:30pm Chicago H		PLATFORM SESSION 6: Environmental Photobiology/Sunscreens, Papers 178-186 Chairs: Helene Hill, New Jersey Medical School, Newark, NJ and John Sutherland, Brookhaven National Laboratory, Upton, NY
2:00pm		The Bystander Effect: Ionizing Radiation and UVA, Paper 178 H. Hill, R. Howell, E. Azzam, S. de Toledo, A. Bishayee and M. Lenarczyk New Jersey Medical School, Newark, NJ
2:15pm		UV Doses of American Children and Adolescents, Paper 179 D. Godar Food and Drug Administration, Rockville, MD
2:30pm		Biological Effects of Polychromatic Light, Paper 180 J. Sutherland Brookhaven National Laboratory, Upton, NY
2:45pm		Effects of Ozone Depletion on DNA Photoproduct Yields at Palmer Station, Antarctica, Paper 181 D. Mitchell1, J. Meador1 and W. Jeffrey2 1The University of Texas M.D. Anderson Cancer Center, Smithville, TX and 2University of West Florida, Pensacola, FL
3:00pm		Role of Plant Phenolics in UV-Protection, Paper 182 J. Bornman1, A. Szilágyi1 and E. Hideg2 1Lund University, Lund, Sweden and 2Biological Research Center, Szeged, Hungary
3:15pm		Break
3:30pm		Modeling Acute Exposure and Dose to Solar Radiation, Paper 183 J. Streicher1, R. Fornaro2, M. Dulberg2, W. Culverhouse2, A. McConnell2, M. Gross2 and M. Heil2 1US Environmental Protection Agency, Research Triangle Park, NC and 2North Carolina State University, Raleigh, NC
3:45pm		Photochemistry and the Origin of Life on Earth, Paper 184 M. Lassota Elk Grove Village, IL
4:00pm		Correlation of Sunscreen Immune and Sun Protection Factors using a Nickel Contact Hypersensitivity Model, Paper 185 T. Poon, R. Barnetson and G. Halliday Royal Prince Alfred Hospital, Camperdown and University of Sydney, Australia
4:15pm		An Improved System for Evaluating Indoor Tanning Industry UVR Sources, Paper 186 B. Grant, D. Smith and P. Reykdal UVR Research Institute, Tucson, AZ
5:00-6:00pm Denver/Houston/ Kansas City		ASP BUSINESS MEETING
6:30-7:30pm 5th Floor Foyer		RECEPTION
7:30-10:30pm Chicago E-H		BANQUET