29th Annual Meeting of the American Society for Photobiology Downtown Marriott Chicago, IL . . . . . . . . . . . . . . . . . . . . . . July 7-12, 2001

THURSDAY, JULY 12

7:00-8:00am Chicago A-D		Continental Breakfast
8:00-9:00am Chicago E		SCHOOL LECTURE V: Molecular Pathways and Photosensitization, Paper 262 Charles Gomer Childrens Hospital of Los Angeles, Los Angeles, CA
9:00-12:00pm Chicago E		SYMPOSIUM 19: Working with Nitric Oxide in Photobiology, Papers 263-267 Chair: Garry Buettner, University of Iowa, Iowa City, IA This symposium sponsored in part by Bruker Instruments, Inc., Calbiochem-Novabiochem Corporation, Cayman Chemical Company, Kimberly-Clark Corporation and Proctor and Gamble Company. Nitric Oxide is now realized to be an extremely important and versatile molecule in biology, including photobiology. The goal of this symposium is to provide attendees with the current thinking on the role of nitric oxide in protecting against detrimental photobiological processes as well as its role in the initiation of normal biological responses to light. Dr. Furchgott (1998 Nobel prize for NO as a signaling molecule) discovered over forty years ago, that light can cause photorelaxation of vascular smooth muscle (action spectrum peak at 310 nm). He will summarize these observations and provide the most current view on the mechanism of this process. Drs. Kalyanaraman and Griffith will present state-of-the-art understanding of tools used in research on nitric oxide and NOS and how research protocols with these tools should be designed and interpreted. The symposium will further provide the newest information on NO and/or NOS in UVA protection, the immune response to light, and photosensitization. In addition new insights on the mechanism of nitric oxide as a cellular antioxidant will be presented.
9:00am		Using Nitric Oxide Donors in Photobiology B. Kalyanaraman Medical College of Wisconsin, Milwaukee, WI
9:30am		Photorelaxation of Vascular Smooth Muscle Cells; The Nitric Oxide Connection, Paper 263 R. Furchgott SUNY Downstate Medical Center, Brooklyn, NY
10:00am		Nitric Oxide Mediates Full Protection from UVA-Induced Cell Death in Endothelial Cells via Two Different Pathways, Paper 264 C. Suschek, O. Schnorr, D. Bruch-Gerharz, K.-D. Kroencke, H. Sies and V. Kolb-Bachofen Heinrich-Heine-University, Dusseldorf, Germany
10:30am		New Developments in Nictric Oxide Synthase Inhibitors O. Griffith Medical College of Wsiconsin, Milwaukee, WI
11:00am		Role of NO in UV Immunosuppression in Humans and Mice, Paper 265 G. Halliday, J. Kuchel, P. Russo, K. Yuen and R. Barnetson Royal Price Alfred Hospital, Campersdown and University of Sydney, Australia
11:30am		Nitric Oxide Sensitizes Cancer Cells to PDT, Paper 266 E. Kelley and G. Buettner The Universityof Iowa, Iowa City, IA
11:40am		Nitric Oxide as a Cellular Antioxidant, Paper 267 G. Buettner, F. Schafer, E. Kelley, K. Cueno, S. Venkataraman and H. Wang The University of Iowa, Iowa City, IA
9:00-12:00pm Chicago F-G		SYMPOSIUM 20: PDT, Genomics and Proteomics in the Crossroad: Photochemistry of Biopolymer-Photosensitizer Complexes, Papers 268-272 Chairs: Lisa Kelly, University of Maryland - Baltimore County, Baltimore, MD and Guilherme Indig, University of Wisconsin, Madison, WI This symposium sponsored in part by Pharmalux LLC and On-Line Instrument Systems. Biopolymers such as proteins, nucleic acids, melanins and humic materials, act as host templates for the noncovalent binding of small molecules. While solvatochromic and fluorescent guests act as reporters of macromolecular structure and dynamics, photoreactive guests can induce damage in the host macromolecules. The photochemistry of non-covalently formed biopolymer-photosensitizer complexes has utility in photodynamic therapy, phototoxicity, and photoalergic responses. In addition, the reactive intermediates provide powerful tools to probe biomolecular structure and interactions. This symposium focuses on mechanisms of macromolecular damage in host-guest complexes of biological relevance, and on state-of-the-art photochemical and photophysical techniques used to initiate and probe the biophysical processes. The mechanisms of nucleic acid and protein damage will be particularly emphasized, as well as the potential of these reactions as technological tools for use in fields of genomics and proteomics.
9:00am		Developing Organic Photosensitizers to Probe Macromolecular Structure and Dynamics, Paper 268 B. Abraham, J. Rogers, S. McMasters, T. Le and L. Kelly University of Maryland, Baltimore County, Baltimore, MD
9:30am		Effect of Self-Association and Biopolymer Binding on the Photonuclease/Photoprotease Activity of Triarylmethane Photosensitizers, Paper 269 G. Indig, J. Bartlett and L. Lewis University of Wisconsin, Madison, WI
10:00am		Kinetics of Guanine Oxidation by Metal Complexes - Roles of Mechanism, Secondary Structure and Medium, Paper 270 H. Thorp, S. Weatherly, I. Yang, T. Leone and R. Murray University of North Carolina, Chapel Hill, NC
10:30am		Break
10:45am		Novel Sensitizers for Photoinactivation of Nucleic Acid, Paper 271 H. Morrison Purdue University, West Lafayette, IN
11:15am		Protein Scissors: Site Specific Photocleavage of Proteins, Paper 272 C. Kumar, A. Buranaprapuk and J. Thota University of Connecticut, Storrs, CT