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Normal Tissue
Tolerance of the Photosensitizer Benzoporphyrin Derivative (Verteporfin)
in an Oral and Laryngeal Canine Model
Teichert, Matthew1,
Usacheva, Marina1 and Biel, Merrill1
Advanced Photodynamic Technologies, Inc.1
Abstract-
Photodynamic therapy (PDT) is a promising technique for cancer treatment.
PDT involves the use of a photosensitizing drug, which is retained in
varying degrees by normal tissues but tends to become concentrated in
tumor cells. The drug is activated by laser light resulting in tumor
destruction. Since normal tissues to some extent retain the photosensitizing
drug, some degree of normal tissue damage may occur once the drug is
activated by laser light at the appropriate wavelength. Previous normal
tissue tolerance studies performed with Photofrin, Npe6, mTHPC, and
SnET2 demonstrated a differential effect of PDT on different tissues
when exposed to the same total light dose conditions. In addition, above
certain total light doses all normal tissues suffered consistent and
severe irreversible damage. This study evaluates the photosensitizer
Benzoporphyrin Derivative (Verteporfin) on normal canine cheek, tongue,
and larynx tissue. Methods and results will be presented.
Keywords: Benzoporphyrin
Derivative, Tissue Tolerance, Verteporfin, Oral & Laryngeal Model
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