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Molecular Pathways
and Photosensitization
Gomer, Charles1,2
Childrens Hospital Los Angeles1
University of Southern California2
Abstract-
The increasing clinical interests and applications of photodynamic therapy
(PDT) are coupled with a concomitant growth in our understanding of
mechanisms of action associated with cellular and in-vivo photosensitization.
The widespread availability and use of molecular/biochemical protocols
have greatly enhanced our ability to evaluate subcellular and cellular
responses initiated by PDT mediated oxidative stress. A myriad of signaling
pathways and gene activation events have been reported to occur following
PDT mediated photosensitization. This lecture will review a variety
of pathways either activated or attenuated by PDT. Potential translational
relevance associated with these molecular responses will also be presented.
Keywords: photodynamic
therapy, PDT, photosensitization, gene activation
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